https://jefflourie.com/Jeff Lourie — dual-certified psychiatric-mental health and family nurse practitioner and former hospital Medical Ethics Committee chair, working at the intersection of clinical care, ethics, and the safety and governance of clinical AI.Hugoen-usMon, 22 Jun 2026 00:00:00 +0000https://jefflourie.com/retrospection/expert-systems-organic-chemistry-claude/Mon, 22 Jun 2026 00:00:00 +0000https://jefflourie.com/retrospection/expert-systems-organic-chemistry-claude/My retrospective analysis of early expert systems thinking compared with Claude's perspective on computational chemistry and AI approaches.https://jefflourie.com/retrospection/generative-ai-sea-change-claude/Thu, 18 Jun 2026 00:00:00 +0000https://jefflourie.com/retrospection/generative-ai-sea-change-claude/My retrospective analysis comparing my earlier thoughts on generative AI with Claude's perspective on the same topic.https://jefflourie.com/field-notes/validation-collapse-safety-inversion/Mon, 15 Jun 2026 00:00:00 +0000https://jefflourie.com/field-notes/validation-collapse-safety-inversion/Large language models (LLMs) are increasingly used for emotional support, coaching, self-reflection, and mental-health-adjacent conversation.https://jefflourie.com/field-notes/naming-the-error/Tue, 02 Jun 2026 00:00:00 +0000https://jefflourie.com/field-notes/naming-the-error/A recurring clinical intuition holds that if patients could only see the faulty machinery of their own thinking — the distortions, the dissonance, the leaps of inference — they would be freed from some part of their suffering.https://jefflourie.com/field-notes/ai-diagnosis-treatment-selection/Sat, 08 Nov 2025 00:00:00 +0000https://jefflourie.com/field-notes/ai-diagnosis-treatment-selection/For many people, primary care has become the first door they knock on—and sometimes the only one—when they are struggling with depression, anxiety, insomnia, the aftermath of trauma, difficulty concentrating, or substance use.https://jefflourie.com/field-notes/clinical-safety-llms/Sun, 02 Mar 2025 00:00:00 +0000https://jefflourie.com/field-notes/clinical-safety-llms/Patient-facing large language models are entering behavioral health, whether the field is ready or not. Some systems are purpose-built for mental health. Others are general commercial AI platforms that become behavioral health tools because users bring them behavioral health questions.https://jefflourie.com/retrospection/generative-ai-sea-change/Sat, 01 Dec 2018 00:00:00 +0000https://jefflourie.com/retrospection/generative-ai-sea-change/Reflections on the potential impact of generative AI in healthcare and medicine.https://jefflourie.com/retrospection/expert-systems-organic-chemistry/Thu, 01 Jan 2004 00:00:00 +0000https://jefflourie.com/retrospection/expert-systems-organic-chemistry/I wrote this a lifetime ago in grad school. I was looking at the application of expert systems in organic chemistry and computational approaches to chemical knowledge, and I wasn't too far off.